Walter J Koch Selected Research

beta-adrenergic receptor kinase inhibitory peptide

10/2010	betaARKct: a therapeutic approach for improved adrenergic signaling and function in heart disease.
1/2009	Myocardial adeno-associated virus serotype 6-betaARKct gene therapy improves cardiac function and normalizes the neurohormonal axis in chronic heart failure.
8/2008	G protein-coupled receptor kinase 2 ablation in cardiac myocytes before or after myocardial infarction prevents heart failure.
12/2005	A Gbetagamma inhibitor reduces intimal hyperplasia in aortocoronary saphenous vein grafts.
9/2005	Reduction of vascular intimal-medial hyperplasia in polytetrafluoroethylene arteriovenous grafts via expression of an inhibitor of G protein signaling.
9/2005	Acute ischemic cardiac dysfunction is attenuated via gene transfer of a peptide inhibitor of the beta-adrenergic receptor kinase (betaARK1).
2/2005	Level of beta-adrenergic receptor kinase 1 inhibition determines degree of cardiac dysfunction after chronic pressure overload-induced heart failure.
10/2004	Catheter-mediated delivery of adenoviral vectors expressing beta-adrenergic receptor kinase C-terminus inhibits intimal hyperplasia and luminal stenosis in rabbit iliac arteries.
4/2004	Targeted beta-adrenergic receptor kinase (betaARK1) inhibition by gene transfer in failing human hearts.
3/2004	Right ventricular targeted gene transfer of a beta-adrenergic receptor kinase inhibitor improves ventricular performance after pulmonary artery banding.

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Walter J Koch Research Topics

Disease

127	Heart Failure 01/2023 - 01/2002
39	Myocardial Infarction 04/2024 - 12/2002
27	Myocardial Ischemia (Ischemic Heart Diseases) 01/2023 - 11/2002
25	Hypertrophy 01/2022 - 01/2002
24	Ischemia 01/2023 - 02/2002
24	Cardiomegaly (Heart Hypertrophy) 01/2022 - 08/2002
17	Infarction (Infarctions) 01/2023 - 08/2004
15	Cardiomyopathies (Cardiomyopathy) 01/2022 - 06/2002
14	Reperfusion Injury 02/2019 - 02/2002
13	Cardiovascular Diseases (Cardiovascular Disease) 04/2024 - 01/2000
10	Left Ventricular Dysfunction 01/2023 - 12/2004
10	Hypertension (High Blood Pressure) 01/2017 - 07/2002
8	Heart Diseases (Heart Disease) 11/2023 - 08/2003
8	Hypoxia (Hypoxemia) 11/2023 - 06/2012
8	Fibrosis (Cirrhosis) 12/2022 - 08/2014
8	Inflammation (Inflammations) 12/2020 - 01/2010
6	Neoplasms (Cancer) 01/2022 - 09/2003
5	Atherosclerosis 01/2017 - 01/2013
5	Ventricular Remodeling 02/2014 - 03/2004
5	Hyperplasia 08/2007 - 01/2004
4	Wounds and Injuries (Trauma) 01/2022 - 05/2008
4	Disease Progression 04/2015 - 09/2006
4	Ventricular Dysfunction 01/2011 - 11/2002
3	Sepsis (Septicemia) 01/2020 - 02/2013
2	Heart Injuries 01/2023 - 02/2010
2	Ischemic Stroke 12/2020 - 10/2003
2	Endotoxemia 01/2020 - 01/2019
2	Cicatrix (Scar) 01/2020 - 01/2019
2	Hyperaldosteronism (Conn Syndrome) 01/2019 - 12/2014
2	Body Weight (Weight, Body) 01/2019 - 11/2007

Drug/Important Bio-Agent (IBA)

28	Phosphotransferases (Kinase)IBA 01/2021 - 01/2002
24	Adrenergic Agents (Adrenergic Drugs)IBA 01/2023 - 01/2000
24	beta Adrenergic ReceptorsIBA 01/2023 - 01/2002
23	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2023 - 12/2004
22	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021 - 08/2003
21	Proteins (Proteins, Gene)FDA Link 01/2023 - 09/2003
20	Peptides (Polypeptides)IBA 01/2021 - 03/2002
18	G-Protein-Coupled Receptor Kinase 2IBA 01/2017 - 09/2003
14	beta-adrenergic receptor kinase inhibitory peptideIBA 10/2010 - 01/2000
12	CatecholaminesIBA 01/2021 - 10/2006
8	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2022 - 05/2007
8	CalciumIBA 01/2019 - 09/2004
8	AldosteroneIBA 01/2019 - 01/2009
7	G-Protein-Coupled Receptor Kinase 5IBA 01/2022 - 04/2012
7	AdiponectinIBA 09/2014 - 02/2010
7	beta-Adrenergic Receptor KinasesIBA 09/2005 - 08/2003
6	G-Protein-Coupled Receptor KinasesIBA 10/2018 - 06/2006
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 10/2016 - 05/2007
5	Protein Isoforms (Isoforms)IBA 11/2023 - 08/2006
5	Erythropoietin FDA Link 01/2022 - 10/2003
5	salicylhydroxamic acid (SHAM)IBA 01/2022 - 05/2008
5	Nitric Oxide (Nitrogen Monoxide)FDA Link 01/2018 - 02/2002
5	Heterotrimeric GTP-Binding Proteins (Heterotrimeric G-Proteins)IBA 01/2017 - 09/2003
5	Insulin (Novolin)FDA Link 12/2015 - 05/2008
5	S100A1 proteinIBA 07/2011 - 01/2002
4	MicroRNAs (MicroRNA)IBA 01/2023 - 08/2014
4	Glucose (Dextrose)FDA LinkGeneric 01/2023 - 08/2008
4	Adenosine (Adenocard)FDA LinkGeneric 01/2022 - 11/2006
4	Isoproterenol (Isoprenaline)FDA LinkGeneric 01/2022 - 05/2008
4	Messenger RNA (mRNA)IBA 01/2020 - 03/2007
4	Interleukin-10 (Interleukin 10)IBA 01/2020 - 12/2015
4	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2020 - 02/2014
4	Reactive Oxygen Species (Oxygen Radicals)IBA 01/2019 - 04/2013
4	Caveolin 3IBA 11/2015 - 03/2011
3	Mitogen-Activated Protein KinasesIBA 11/2023 - 12/2005
3	LipidsIBA 01/2023 - 08/2008
3	LigandsIBA 01/2019 - 09/2003
3	Phenylephrine (Neo-Synephrine)FDA LinkGeneric 01/2018 - 11/2002
3	Angiotensin IIIBA 04/2016 - 11/2002
3	Neurotransmitter Agents (Neurotransmitter)IBA 02/2014 - 01/2002
3	Transcription Factors (Transcription Factor)IBA 12/2013 - 06/2002
2	Estrogens (Estrogen)FDA Link 04/2024 - 02/2002
2	Protein Kinases (Protein Kinase)IBA 11/2023 - 08/2006
2	Glycogen Synthase Kinase 3IBA 11/2023 - 07/2010
2	Metoprolol (Toprol-XL)FDA LinkGeneric 01/2023 - 01/2015
2	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 01/2002
2	Fibroblast Growth Factor 2 (Basic Fibroblast Growth Factor)IBA 01/2022 - 09/2008
2	cytidylyl-(3'-5')-cytidine (CpC)IBA 01/2022 - 04/2018
2	erucylphosphocholineIBA 01/2022 - 01/2020
2	Neutralizing AntibodiesIBA 12/2020 - 01/2019
2	Peptide Hydrolases (Proteases)FDA Link 12/2020 - 01/2005
2	CaspasesIBA 12/2020 - 01/2005
2	Circular RNAIBA 01/2020 - 01/2019
2	Monoclonal AntibodiesIBA 01/2020 - 02/2019
2	Therapeutic UsesIBA 01/2020 - 10/2010
2	Angiotensin Receptor AntagonistsIBA 10/2019 - 12/2014
2	CytokinesIBA 01/2019 - 02/2013
2	Transforming Growth Factors (Transforming Growth Factor)IBA 01/2019 - 09/2017
2	Complementary DNA (cDNA)IBA 01/2019 - 08/2006
2	Doxycycline (Periostat)FDA LinkGeneric 01/2019 - 08/2011
2	Superoxides (Superoxide)IBA 01/2018 - 01/2013
2	Adenosine Triphosphatases (ATPase)IBA 11/2017 - 03/2011
2	Paroxetine (Paxil)FDA LinkGeneric 10/2017 - 03/2015
2	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2017 - 01/2002

Therapy/Procedure

33	Therapeutics 01/2022 - 07/2003
12	Ligation 01/2023 - 07/2002
3	Injections 04/2024 - 01/2018
3	Heart Transplantation (Grafting, Heart) 05/2008 - 03/2004
2	Transplantation 11/2021 - 12/2015
2	Punctures 01/2019 - 01/2019